Experimental evaluation of beneficial potential of Rhizophora mucronata Lam. leaves in Cisplatin-induced nephrotoxic animal model
DOI:
https://doi.org/10.7439/ijbr.v9i2.4645Keywords:
Antibiotic sensitivity, biochemical tests coagulase negative Staphylococci, methicillin resistanceAbstract
Objective: Chronic kidney disease typically evolves over many years, with a long latent period when the disease is clinically silent. Diagnosis, progression and treatment of renal impairment are based mainly on biomarkers that assess kidney function. There are a number of drugs used in the therapeutics which possesses nephrotoxic properties. But till date there is no nephroprotective drug available in therapeutics. In recent years the popularity of the herbal drugs is increased for their safety, efficacy and cost effectiveness. They have also gain importance in the drug development research. Present study has been focused to evaluate the preventive effect of the ethanolic extract of Sunderban mangrove Rhizophora mucronata Lam. leaves (RME) against cisplatin induced nephrotoxicity in experimental animal model.Downloads
References
Hayati F, Hossainzadeh M, Shayanpour S, Abedi-Gheshlaghi Z, Beladi Mousavi SS. Prevention of cisplatin nephrotoxicity. Journal of Nephropharmacology 2016;5(1):57-60.
Wen CP, Matsushita K, Coresh J et al. Relative risks of Chronic Kidney Disease for mortality and End Stage Renal Disease across races is similar. Kidney international 2014;86(4):819-827.
Bhandari S, Galanello R. Renal aspects of thalassaemia a changing paradigm. Eur J Haematol 2012;89(3):187–197.
Hanigan MH, Devarajan P. Cisplatin nephrotoxicity: molecular mechanisms. Cancer therapy 2003;1:47-61.
Dos Santos NA, Carvalho Rodrigues MA, Martins NM, Dos Santos AC. Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update. Arch Toxicol 2012;86:1233-50.
Imdadul H et al. Valuable Antioxidant and Antimicrobial Extracts from Rhizophora Mucronata of Asiatic Mangrove Forests. Research Journal of Biotechnology 2011;6(1): 10.
Bandaranayake WM. Traditional and medicinal uses of mangroves. Manage Salt Marshes 1998;2:133–48.
Ray M, Adhikari A, Sur TK, Mondal C, Pathak A, Das AK. Pharmacognostic and Anti-Hyperglycemic Evaluation of the Leaves of Sunderban Mangrove, Rhizophora mucronata L. Pharmanest 2014;5(5):2289-2294.
Sur TK, Hazra AK, Bhattacharyya D, Hazra A. Antiradical and antidiabetic properties of standardized extract of Sunderban mangrove Rhizophora mucronata. Pharmacog Mag 2015;11:389-94.
Ray M, Adhikari A, Sur TK, Besra SE, Biswas S and Das AK. Evaluation of Anti-Inflammatory Potential of Ethanolic Extract of the Leaves of Rhizophora Mucronata, a Sunderban Mangrove. Int J Res Dev Pharm L Sci 2017;6(2):2510-2511.
Motamedi F, Nematbakhsh M, Monajemi R, et al. Effect of pomegranate flower extract on cisplatin-induced nephrotoxicity in rats. Journal of Nephropathology 2014;3(4):133-138.
Pani SR, Mishra S, Sahoo S, Panda PK. Nephroprotective effect of Bauhinia variegata (Linn.) whole stem extract against cisplatin-induced nephropathy in rats. Indian J Pharmacol 2011; 43(2): 200–202.
Nasri H. Cisplatin and renal injury; current concepts. Journal of Renal Injury Prevention 2013;2(3):89-90.
Nematbakhsh M, Hajhashemi V, Ghannadi A, Talebi A, Nikahd M. Protective effects of the Morus alba L. leaf extracts on cisplatin-induced nephrotoxicity in rat. Research in Pharmaceutical Sciences 2013;8(2):71-77.
Abdel Moneim AE, Othman MS, Aref AM. Azadirachta indica Attenuates Cisplatin-Induced Nephrotoxicity and Oxidative Stress. BioMed Research International 2014;2014:647131.
Mirazi N, Movassagh S-N, Rafieian-Kopaei M. The protective effect of hydro-alcoholic extract of mangrove (Avicennia marina L.) leaves on kidney injury induced by carbon tetrachloride in male rats. Journal of Nephropathology 2016;5(4):118-122.
Adhikari A, Ray M, Sur TK, Kanjilal S, Roy RK, Das AK. Analgesic actions of Sunderban mangrove, Rhizophora mucronata L. leaves. Journal of Medicinal Plants Studies 2016; 4(3): 140-143.
Lopez-Giacoman S, Madero M. Biomarkers in chronic kidney disease, from kidney function to kidney damage. World Journal of Nephrology 2015;4(1):57-73.
Pinches M, Betts C, Bickerton S, Burdett L, Thomas H, Derbyshire N. et al. Evaluation of novel renal biomarkers with a cisplatin model of kidney injury: gender and dosage differences. Toxicol Pathol. 2012;40:522–33.
Campion CG, Sanchez-Ferras O, Batchu SN. Potential Role of Serum and Urinary Biomarkers in Diagnosis and Prognosis of Diabetic Nephropathy. Canadian Journal of Kidney Health and Disease 2017;4:2054358117705371.
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