A comparison of fentanyl and clonidine as adjuvants to intrathecal levobupivacaine for spinal anaesthesia and postoperative analgesia in patients undergoing for lower limb surgery

Authors

  • Archana Agarwa Department of Anaesthesiology, Hind Institute of Medical Sciences, Near Lucknow, Uttar Pradesh
  • Rajiv Lakhotia Department of Anaesthesiology, Hind Institute of Medical Sciences, Near Lucknow, Uttar Pradesh
  • Somnath Longwani Department of Anaesthesiology, Hind Institute of Medical Sciences, Near Lucknow, Uttar Pradesh
  • Sandeep Srivastava Department of Anaesthesiology, Hind Institute of Medical Sciences, Near Lucknow, Uttar Pradesh
  • Amit Kumar Srivastava Department of Anaesthesiology, Hind Institute of Medical Sciences, Near Lucknow, Uttar Pradesh
  • Jaishri Bogra Department of Anaesthesiology, Hind Institute of Medical Sciences, Near Lucknow, Uttar Pradesh

DOI:

https://doi.org/10.7439/ijbr.v9i2.4622

Abstract

Objective: Analgesic adjuvants, clonidine

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References

McLeod GA and Burke D. Levobupivacaine. Anesthesia 2001; 56: 331–341.

McCellan KJ and Spencer CM. Levobupivacaine. Drugs 1998; 56: 355–362.

MacKenzie TA and Young ER. Local anesthetic update. Anesth Prog 1993;40:29–34.

Prakash S, Joshi N, Gogia AR, Prakash S, Singh R. Analgesic efficacy of two doses of intrathecal midazolam with bupivacaine in patients undergoing cesarean delivery. Reg Anesth Pain Med 2006;31:221-226.

Yoganarasimha N, Raghavendra T, Amitha S, Shridhar K, Radha M. A comparative study between intrathecal clonidine and neostigmine with intrathecal bupivacaine for lower abdominal surgeries. Indian J Anaesth 2014;58:43-7.

Benhamou D, Thorin D, Brichant JF, Dailland P, Milon D, Schneider M. Intrathecal clonidine and fentanyl with hyperbaric bupivacaine improves analgesia during cesarean section. Anesth Analg 1998;87:609-613.

Kothari N, Bogra J, Chaudhary AK. Evaluation of analgesic effects of intrathecalclonidine along with bupivacaine in cesarean section. Saudi J Anaesth 2011;5:31-35.

Bajwa SJ, Bajwa SK, Kaur J, Singh A, Singh A, Parmar SS. Prevention of hypotension and prolongation of postoperative analgesia in emergency cesarean sections: A randomized study with intrathecal clonidine. Int j crit illn inj sci 2012;2:63-69.

Elia N, Culebras X, Mazza C, Schiffer E, Tramèr MR. Clonidine as an adjuvant to intrathecal local anesthetics for surgery: Systematic review of randomized trials. Reg Anesth Pain Med 2008;33:159-167.

Wang JK, Nauss LA, Thomas JE. Pain relief by intrathecally applied morphine in man. Anesthesiology 1979;50:149-151.

Selvaraju KN, Sharma SV. Comparison of forced expiratory spirometric flow changes following intrathecal bupivacaine and bupivacaine with fentanyl. South Afr J Anesth Analg 2008;14:33-37.

De Kock M. Site of hemodynamic effects of alpha 2‑adrenergic agonists. Anesthesiology 1991;75:715-716.

Bonnet F, Buisson VB, Francois Y, Catoire P, Saada M. Effects of oral and subarachnoid clonidine on spinal anesthesia with bupivacaine. Reg Anesth 1990;15:211-214.

Sethi BS, Samuel M, Sreevastava D. Efficacy of analgesic effects of low dose intrathecal clonidine as adjuvant to bupivacaine. Indian J Anaesth 2007;51:415-419.

Shah BB, Shidhaye RV, Divekar DS, Panditrao M, Panditrao MM, Suryawanshi C. Effect of addition of clonidine to bupivacaine used for patients undergoing spinal anaesthesia: A randomized, double blind, controlled study. Sri Lankan J Anaesthesiol 2011;19:17-21.

Chung CJ, Choi SR, Yeo KH, Park HS, Lee SI, Chin YJ. Hyperbaric spinal ropivacaine for cesarean delivery: A comparison to hyperbaric bupivacaine. Anesth Analg 2001;93:157–161.

Bromage PR. Philadelphia: WB Saunders; 1978. Epidural analgesia; p. 144.

Lee YY, Mucchal K, Chan CK. Levobupivacaine versus racemic bupivacaine in spinal anaesthesia for urological surgery. Anaesth Intens Care 2003;31:637–641.

Camorcia M, Capogna G, Berrita C, Columb MO. The relative potencies for motor block after intrathecal ropivacaine, levobupivacaine, and bupivacaine. Anaesth Analg 2007;104:904–907.

Akcaboy EY, Akcaboy ZN, Gogus N. Low dose levobupivacaine 0.5% with fentanyl in spinal anaesthesia for transurethral resection of prostate surgery. J Res Med Sci 2011;16:68-73.

Lacassie HJ, Columb MO. The relative motor blocking potencies of bupivacaine and levobupivacaine in labor. Anesth Analg 2003;97:1509–13.

Bajwa BS, Singh AP, Rekhi AK. Comparison of intrathecal clonidine and fentanyl in hyperbaric bupivacaine for spinal anesthesia and postoperative analgesia in patients undergoing lower abdominal surgeries. Saudi J Anaesth 2017;11:37-40.

Routray SS, Raut K, Pradhan A, Dash A, Soren M. Comparison of Intrathecal Clonidine and Fentanyl as Adjuvant to Hyperbaric Bupivacaine in Subarachnoid Block for Lower Limb Orthopedic Surgery. Anesth Essays Res 2017;11:589-593.

Benhamou D, Thorin D, Brichant JF, Dailland P, Milon D, Schneider M. Intrathecal clonidine and fentanyl with hyperbaric bupivacaine improves analgesia during cesarean section. Anesth Analg 1998;87:609–613.

Kothari N, Bogra J, Chaudhary AK. Evaluation of analgesic effects of intrathecal clonidine along with bupivacaine in cesarean section. Saudi J Anaesth 2011;5:31–35.

Bajwa SJ, Bajwa SK, Kaur J, Singh A, Singh A, Parmar SS. Prevention of hypotension and prolongation of postoperative analgesia in emergency cesarean sections: A randomized study with intrathecal clonidine. Int J Crit Illn Inj Sci 2012;2:63–69.

Breen TW, Shapiro T, Glass B, Foster-Payne D, Oriol NE. Epidural anesthesia for labor in an ambulatory patient. Anesth Analg 1993;77:919–924.

Agrawal A, Agrawal S, Asthana V, Payal YS, Sharma J, Gupta V. Comparison of intrathecal fentanyl and sufentanil in addition to bupivacaine for caesarean section under spinal anaesthesia. J Anaesth Clin Pharmacol 2009;25:154–156.

Sharan R, Verma R, Dhawan A, Kumar J. Comparison of clonidine and fentanyl as adjuvant to ropivacaine in spinal anesthesia in lower abdominal surgeries. Anesth Essays Res 2016;10:526-531.

Ogun C, Kirgiz E, Duman A, Kara I, Okesli S. The comparison of intrathecal isobaric ropivacaine and isobaric ropivacaine-clonidine for caesarean delivery. Internet J Anesthesiol 2006;15:1.

Chaudhary A, Bogra J, Singh PK, Saxena S, Chandra G, Verma R. Efficacy of spinal ropivacaine versus ropivacaine with fentanyl in transurethral resection operations. Saudi J Anaesth 2014;8:88–91.

Yegin A, Sanli S, Hadimioglu N, Akbas M, Karsli B. Intrathecal fentanyl added to hyperbaric ropivacaine for transurethral resection of the prostate. Acta Anaesthesiol Scand 2005;49:401–405.

Sethi BS, Samuel M, Sreevastava D. Efficacy of analgesic effects of low dose intrathecal clonidine as adjuvant to bupivacaine. Indian J Anaesth 2007;51:415–419.

Shah BB, Shidhaye RV, Divekar DS, Panditrao M, Panditrao MM, Suryawanshi C. Effect of addition of clonidine to bupivacaine used for patients undergoing spinal anaesthesia: A randomized, double blind, controlled study. Sri Lankan J Anaesthesiol 2011;19:17–21.

Biswas BN, Rudra A, Bose BK, Nath S, Chakrabarty S, Bhattacharjee S. Intrathecal fentanyl with hyperbaric bupivacaine improves analgesia during caesarean delivery and in early post operative period. Indian J Anaesth 2002;46:469–472.

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Published

2018-03-03

Issue

Vol. 9 No. 2 (2018): Feb

Section

Original Research Articles

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How to Cite

1.
A comparison of fentanyl and clonidine as adjuvants to intrathecal levobupivacaine for spinal anaesthesia and postoperative analgesia in patients undergoing for lower limb surgery. Int Jour of Biomed Res [Internet]. 2018 Mar. 3 [cited 2026 Mar. 17];9(2):76-80. Available from: https://www.ssjournals.co.in/index.php/ijbr/article/view/4622