A study on Liver function tests and Renal function tests in Preeclampsia
DOI:
https://doi.org/10.7439/ijbr.v7i10.3671Abstract
Background: Preeclampsia is a multisystem disorder, which occurs only in pregnant women during the second and third trimesters of pregnancy and is associated with raised blood pressure and proteinuria. Liver Function Test (LFT) abnormalities occur in 3% of the pregnancies and probably the lesion that causes elevated serum liver enzymes. With severe renal involvement, glomerular filtration may be impaired and the plasma creatinine concentration may begin to rise. Elevated uric acid is another component of the preeclampsia. Materials and Methods: The study was conducted on 70 pregnant women admitted with preeclampsia and eclampsia and 35 normal pregnancy patients in between 19-26 years of age in third trimester of pregnancy from January 2012 to June 2013. Investigations like complete hemogram, liver function tests, renal function tests, coagulation profile, fundus and 24 hours urine for protein were done for all study subjects. Results: In the present study, in case of mild pre eclampsia, there is elevation of blood urea and serum creatinine but it is not statistically significant, where as in case of severe preeclampsia and eclampsia the elevated values are statistically significant. In the present study, serum uric acid levels are significantly elevated in mild preeclampsia, severe preeclampsia and eclampsia. In the present study, all the Liver function test except serum bilirubin are significantly elevated, but the elevation of serum bilirubin was not statistically significant. Conclusion: There is a derangement of parameters of RFT and LFT in severe preeclampsia and eclampsia. It may be advised to perform serum uric acid and ALT in preeclampsia and eclampsia to confirm involvement of renal and liver functions.Downloads
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