Diagnostic value of CSF C-reactive protein in meningitis: A prospective study
DOI:
https://doi.org/10.7439/ijbr.v7i6.3380Abstract
Objective : To establish diagnostic role of CSF C-reactive protein quantitatively in meningitis. Method: It is a prospective observational study conducted at tertiary care centre in south Rajasthan. Total 100 patients were included and allocated into three groups based on clinical signs and symptoms; group-I Bacterial meningitis (n=50), group-II Tubercular meningitis (n=30) and group-III Control group (n=20). Along with other appropriate investigations, quantitative CSF C-reactive protein (CRP) was assayed and data were analysed to set a diagnostic level and sensitivity and specificity of CSF C-reactive protein (CRP) in meningitis Result : In group-I patients CSF CRP value was 3.172.68 g/ml; in group-II CSF CRP value was 0.080.12 g/ml and in group-III CSF CRP value was 0.030.02 g/ml. The CSF CRP value in bacterial meningitis is significantly higher than tubercular meningitis and control (P value 0.001). The CSF CRP value >0.1 g/ml has sensitivity 98.07%, specificity 96.00%, positive predictive value 96.22%, and negative predictive value 97.95%. Conclusion : CSF CRP can easily differentiate bacterial meningitis from other meningitis with greater sensitivity and specificity.Downloads
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