A comparative study of effect of two different doses of dexmedetomidine for attenuating the haemodynamic response of laryngoscopy and endotracheal intubation

Abstract

Objectives: To compare effectiveness of two different loading doses: 0.6 g/kg versus 1g/kg of Dexmedetomidine for control of hemodynamic changes during endotracheal intubation. Materials and Methods: In this prospective interventional study, 60 patients of ASA-I and ASA-II scheduled for elective surgeries under general anesthesia were randomly divided into two groups Group D_0.6 (Inj. Dexmedetomidine dose 0.6?g/kg iv) and Group D₁ (Inj. Dexmedetomidine dose 1?g/kg iv. Pulse, blood pressure, ECG were monitored continuously and recorded before giving the study drug, at 5 and 10 min infusion of the study drug, at induction, at intubation, then at 1,5,10 minutes after intubation. Data were analysed and p 0.05 was considered significant. Results: At 5 minutes and 10 minutes of drug infusion, Group D₁ had statistically significant fall in HR as compared to Group D_0.6(13.5% and 21.2% versus 3.9% and 7.8%)_. Maximum fall in mean HR was observed at 10 minutes after intubation in Group D0.6 (25.1%) and at 10 minutes of drug infusion in Group D1(21.23%) At 5 and 10 min of drug infusion, there was fall (23.6%) in SBP from baseline in group D_0.6, while Group D₁ showed transient rise (5.74%) from baseline in SBP, which was highly significant difference statistically ( p 0.0001) The maximum fall in SBP in both groups was observed at 10 minutes following intubation. Conclusion: dexmedetomidine at 0.6 g/kg loading dose provides significantly better attenuation of haemodynamic responses of laryngoscopy and endotracheal intubation unaccompanied by transient hypertension and bradycardia, which is observed at 1 g/kg loading dose.