Study of thyroid dysfunction in type 2 diabetes mellitus patients of Agra city

Authors

  • Alok Mawar Department of Biochemistry, Sarojini Naidu Medical College, Agra
  • Pawan Kumar Kare Department of Biochemistry, University College of Medical Sciences, Delhi,
  • Kamla Pati Mishra Department of Biochemistry, LLRM Medical College, Meerut, U.P., India
  • Raj Kumari Chahar Department of Biochemistry, S.N. Medical College, AGRA, U.P., INDIA

DOI:

https://doi.org/10.7439/ijbr.v7i1.2858

Abstract

Background: Type 2 Diabetes Mellitus (Type 2DM) and associated thyroid dysfunctions are very common in Indian population. Studies on the relationship between diabetes mellitus and thyroid dysfunction are very few in North Indian population. Due to the lack of adequate information about this relationship may be responsible for diabetic patients who may have developed thyroid dysfunction. Methods: The objective of this study was to investigate the thyroid dysfunction in type 2 diabetes mellitus patients of Agra city. The study population consisted of (n = 100) subjects divided into two groups: diabetic group (n = 50) and non-diabetic (n = 50) as healthy control group. The biochemical parameters like; fasting plasma glucose, total triiodothyronine (T3), total thyroxine (T4) and thyroid stimulating hormone (TSH) were measured for assessment of thyroid dysfunction. Results: A significant increase in the level of fasting plasma glucose was observed in diabetic patients as compared to healthy controls. In our results, the level of T3 and T4 did not change significantly in diabetic subjects as compared to the control subjects. The serum TSH level was significantly higher in diabetic patients as compared to healthy control subjects. Conclusion: The present study identified the patients at risk with subclinical hypothyroidism in type 2 diabetes. Therefore, the screening of thyroid dysfunction in type 2 DM patients is essential to reduce the severity of disease and endocrinal abnormalities in diabetic patients.

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Author Biographies

  • Alok Mawar, Department of Biochemistry, Sarojini Naidu Medical College, Agra
    ASSISTANT PROFESSOR, DEPARTMENT OF BIOCHEMISTRY, S.N. MEDICAL COLLEGE, AGRA, U.P., INDIA
  • Pawan Kumar Kare, Department of Biochemistry, University College of Medical Sciences, Delhi,
    PhD Research Scholar, Department of Biochemistry, University College of Medical Sciences, Delhi, India.
  • Kamla Pati Mishra, Department of Biochemistry, LLRM Medical College, Meerut, U.P., India
    Professor, Department of Biochemistry, LLRM Medical College, Merrut, U.P., India
  • Raj Kumari Chahar, Department of Biochemistry, S.N. Medical College, AGRA, U.P., INDIA
    M.Sc. Student, Department of Biochemsitry, S.N.Medical College, AGRA, U.P., INDIA

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Published

2016-01-30

Issue

Vol. 7 No. 1 (2016): Jan

Section

Original Research Articles

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How to Cite

1.
Study of thyroid dysfunction in type 2 diabetes mellitus patients of Agra city. Int Jour of Biomed Res [Internet]. 2016 Jan. 30 [cited 2026 Mar. 15];7(1):26-9. Available from: https://www.ssjournals.co.in/index.php/ijbr/article/view/2858