Methylenetetrahydrofolate Reductase (MTHFR C677T) Polymorphism in Sudanese Patients with Deep Vein Thrombosis

Authors

  • Hana O. M. Elhassan Department of Haematology, Faculty of Medical Laboratory Sciences, Alneelain University
  • Mahdi Abdalla Department of Haematology, Faculty of Medical Laboratory Sciences, Omdurman Ahlia University

DOI:

https://doi.org/10.7439/ijbr.v6i5.2023

Abstract

Deep vein thrombosis (DVT) is a common cause of morbidity and mortality, particularly in older people. Many genetic polymorphisms are considered as a risk factor of Hypercoagulability in DVT. MTHFR C677T polymorphism is reported to be associated with hyperhomocysteinemia through its inability to convert homocystein to methionnine which lead to hypercoagulable state that may promote DVT. The aim of this study was to examine the association of MTHFR (C677T) polymorphism with the risk of DVT in Sudan. The study included 50 DVT patients, their MTHFR C677T genotype frequencies (detected by PCR/RFLP) and haematological charecteristics (measured by Sysmex KX-21N) were determined and compared with 50 age and sex matched normal subjects as control. Low frequency of mutant MTHFR C677T genotype with 0% TT genotype (homozygote) and 12% CT (heterozygote) was observed. Our study showed a statistically insignifi

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Published

2015-05-30

Issue

Vol. 6 No. 5 (2015): May

Section

Original Research Articles

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How to Cite

1.
Methylenetetrahydrofolate Reductase (MTHFR C677T) Polymorphism in Sudanese Patients with Deep Vein Thrombosis. Int Jour of Biomed Res [Internet]. 2015 May 30 [cited 2026 Mar. 17];6(5):323-6. Available from: https://www.ssjournals.co.in/index.php/ijbr/article/view/2023