Inducible and constitutive clindamycin resistance in Staphylococcus aureus: an experience from Western Nepal

Authors

  • Prakash Sah Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal
  • Rita Khanal Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal
  • Pramila Lamichhane Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal
  • Sweety Upadhaya Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal
  • Apsana Lamsal Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal
  • Vijay Kumar Pahwa Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal

DOI:

https://doi.org/10.7439/ijbr.v6i5.1959

Keywords:

Recto- peritoneal pelvic cyst, degenerative cysts, Surgical excision, C.T, MRI, Histopathology

Abstract

Objective: This study aimed to determine prevalence of inducible and constitutive clindamycin resistance among clinical S. aureus isolates and also study their association with methicillin resistance. Methods: A cross-sectional study including 140 non-duplicate isolates of S. aureus was done. Isolates were identified by standard microbiological methods and methicillin resistance was detected by cefoxitin disc diffusion method. Inducible clindamycin resistance was detected by D-test. Results: Prevalence of inducible and constitutive clindamycin resistance was 12.10% and 7.90% respectively. Constitutive and inducible resistance was associated with MRSA. An unusual phenotype, erythromycin sensitive and clindamycin resistance, was detected in 2 MRSA isolates. Conclusions: Inducible and constitutive clindamycin resistance is low in our setting. Constitutive and inducible resistance was associated with MRSA. However the trends in resistance vary in different places. D-test reporting should be done routinely which will allow clinicians to opt for clindamycin judiciously and avoid potential treatment failure.

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Author Biographies

  • Prakash Sah, Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal

    Assistant professor

    Department of microbiology

  • Rita Khanal, Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal

    Assistant professor

    Department of microbiology

  • Pramila Lamichhane, Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal

    lecturer

    department of microbiology

  • Sweety Upadhaya, Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal

    lecturer

    department of microbiology

  • Apsana Lamsal, Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal

    lecturer

    department of microbiology

  • Vijay Kumar Pahwa, Department of Microbiology Universal College of Medical Sciences Bhairahawa, Nepal

    Professor

    HOD

    Department of microbiology

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Published

2015-05-30

Issue

Vol. 6 No. 5 (2015): May

Section

Original Research Articles

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How to Cite

1.
Inducible and constitutive clindamycin resistance in Staphylococcus aureus: an experience from Western Nepal. Int Jour of Biomed Res [Internet]. 2015 May 30 [cited 2026 Mar. 15];6(5):316-9. Available from: https://www.ssjournals.co.in/index.php/ijbr/article/view/1959