Gastroenteropancreatic Neuroendocrine Tumours An Institutional Experience

Abstract

Objectives : 1)Tostudy thehistomorphological spectrum of gastroenteropancreatic neuroendocrine tumours(GEP NETs) and to analyze it`sclinicopathological features. 2) To classify the GEP-NETs as per WHO 2010 classification system.3) To analyze the expression of the NET marker Neuron specific enolase (NSE) in the above histomorphological spectrum. Methods : A retrospective study was done with collected cases of GEP-NET (over 7 year period) .Clinical data was collected from medical records.The histopathology slides were retrievedfrom archives and reviewed.Immunohistochemical (IHC) studieswere done with marker NSE. Results: The study included 11 cases of GEP-NETs. The age of the patients ranged from 13 to 65 years. The most common anatomic location was the appendix and colon with 3 cases each (27.27%). Most of the tumours were gradeI (6 cases). None of the tumours were associated with carcinoid syndrome. Six out of eleven cases had metastasis at time of diagnosis (54.54%). IHC studies done with NSEresulted in positivity seen in all 10 casesin which it was done. Conclusions : Gastroenteropancreatic neuroendocrine tumours are rare and occur over a wide age range. Most of these tumours present late with metastasis at time of diagnosis. The most common location of these tumours were in the appendix and proximal colon. NSE is a good marker for these tumours and is beneficial in confirming the diagnosis.